منابع مشابه
Proliferation in murine epidermis after minor mechanical stimulation. Part 2. Alterations in keratinocyte cell cycle fluxes.
We have recently shown that a mild mechanical irritation (tape strip) of the epidermis on the back skin of adult mice induces a strong and long lasting increase in proliferative activity and cell production. This was revealed by following the fate of 3HTdR-pulse labelled cells within the basal and suprabasal layers. To obtain further insight into the dynamics of cell kinetic changes we also per...
متن کاملOrnithine decarboxylase activity, cell proliferation, and tumor promotion in mouse epidermis in vivo.
The effect of different phorbol esters and of mechanical treatment on the activity of ornithine decarboxylase in mouse epidermis in vivo was investigated. The strong promoter 12-O-tetradecanoylphorbol-13-acetate as well as the weak promoters phorbol dibenzoate and the 12-O-tetradecanoylphorbol-13-acetate analog 12-O-tetradeca-2-cis, 4-trans-6,8-tetraenoylphorobol-13-acetate strongly increased t...
متن کاملNuclear binding of tritiated actinomycin in basal cell carcinoma and in normal human epidermis.
cantly higher nuclear fixation of the labeled antibiotic was measured in all cases in basal cell carcinoma, fixed with formalin or with alcohol:acetic acid. This suggests that chromatin in the carcinoma is less repressed than in normal basal cells, a conclusion which is in agreement with our present knowledge of this particular type of epidermal tumor, known to be able to evolve towards more or...
متن کاملCell proliferation and apoptosis in normal liver and preneoplastic foci.
The growth rate of tissues including tumors is determined by the difference between cell replication and cell death. Among different types of cell death, apoptosis, a form of programmed cell death, is of particular importance. Nongenotoxic carcinogens exert their carcinogenic effects not only via stimulation of cell replication but also by modulating the incidence of apoptosis. This can be seen...
متن کاملType XVII collagen coordinates proliferation in the interfollicular epidermis
Type XVII collagen (COL17) is a transmembrane protein located at the epidermal basement membrane zone. COL17 deficiency results in premature hair aging phenotypes and in junctional epidermolysis bullosa. Here, we show that COL17 plays a central role in regulating interfollicular epidermis (IFE) proliferation. Loss of COL17 leads to transient IFE hypertrophy in neonatal mice owing to aberrant Wn...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 1984
ISSN: 0022-202X
DOI: 10.1111/1523-1747.ep12261462